Pathological Laughter Following Intravenous Sodium Valproate

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Pathological laughter following intravenous sodium valproate.

BACKGROUND Pathological laughter can be a sign of epilepsy, psychiatric illness, effect of toxins or psychotropic drugs or of structural brain disease. METHOD Case Studies. RESULT Two patients developed inappropriate uncontrollable laughter following intravenous sodium valproate for treatment of epilepsy. CONCLUSION Pathological laughter can be a side effect of intravenous sodium valproate.

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Altered cortical thickness following prenatal sodium valproate exposure

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills a...

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Levetiracetam vs sodium valproate

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Sodium valproate and pregnancy.

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ژورنال

عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

سال: 1998

ISSN: 0317-1671,2057-0155

DOI: 10.1017/s0317167100034107